iNKT cells in microbial immunity: recognition of microbial glycolipids
نویسندگان
چکیده
منابع مشابه
Recognition of Microbial Glycolipids by Natural Killer T Cells
T cells can recognize microbial antigens when presented by dedicated antigen-presenting molecules. While peptides are presented by classical members of the major histocompatibility complex (MHC) family (MHC I and II), lipids, glycolipids, and lipopeptides can be presented by the non-classical MHC member, CD1. The best studied subset of lipid-reactive T cells are type I natural killer T (iNKT) c...
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The discovery that T cells recognize lipid and glycolipid molecules presented by CD1 proteins has greatly expanded the number of potential microbial antigens targeted by the immune system following infection. The ability of CD1d-restricted NKT cells to activate innate and adaptive immune responses has led to the idea that these cells can modulate immunity to infectious agents. In addition, CD1d...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2011
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.2011.00338.x